SYRE - Spyre Therapeutics, Inc.
Price:
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--
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CONSENSUS:
Buy
DETAILS
|
PRICE TARGET:
$85.45
DETAILS
HIGH:
$107.00
LOW:
$49.00
MEDIAN:
$90.00
CONSENSUS:
$85.45
UPSIDE:
15.40%
| Metric | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | ||||||||||||
| Revenue | 0 | 0 | 0.9 | 2.3 | 18.7 | 0 | 0 | 3.9 | 5.2 | 4.6 | 6.1 | 0 |
| Cost of Revenue | 171.7 | 0 | 0 | 0 | 0 | 1.6 | 0.9 | 0 | 0 | 0 | 0 | 0.0 |
| Gross Profit | (171.7) | 0 | 0.9 | 2.3 | 18.7 | (1.6) | (0.9) | 0 | 0 | 0 | 0 | (0.0) |
| Operating Expenses | ||||||||||||
| R&D Expenses | 171.7 | 162.8 | 89.5 | 58.6 | 57.1 | 59.6 | 64.6 | 36.7 | 22.8 | 18.1 | 11.5 | 6.8 |
| SG&A Expenses | 47.9 | 45.8 | 39.9 | 28.5 | 27.3 | 20.2 | 14.8 | 12.6 | 10.1 | 8.4 | 5.9 | 2.1 |
| Other Expenses | (181.7) | 0 | 113.7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Operating Expenses | 37.9 | 208.6 | 243.2 | 87.1 | 84.4 | 79.9 | 79.4 | 49.4 | 32.9 | 26.5 | 17.4 | 8.9 |
| Operating Income | ||||||||||||
| Operating Income | (209.6) | (208.6) | (242.3) | (84.8) | (65.6) | (81.5) | (80.3) | (45.5) | (27.7) | (21.9) | (11.3) | (8.9) |
| Interest Expense | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Interest Income | 24.9 | 21.3 | 6.1 | 0.8 | 0.1 | 0.6 | 2.1 | 1.2 | 0.5 | 0.2 | 0.0 | 0.0 |
| Profitability | ||||||||||||
| EBITDA | (209.6) | (208.0) | (127.6) | (82.8) | (64.1) | (79.3) | (77.4) | (45.2) | (27.4) | (21.8) | (11.2) | (10.3) |
| EBIT | (219.6) | (208.0) | (128.6) | (84.8) | (65.6) | (80.9) | (78.3) | (45.5) | (27.7) | (21.9) | (11.3) | (10.3) |
| Income Before Tax | (155.2) | (208.0) | (338.8) | (84.0) | (65.7) | (80.9) | (78.3) | (44.3) | (27.2) | (21.7) | (11.3) | (10.3) |
| Income Tax Expense | (0.0) | 0.1 | (0.0) | (0.1) | 0.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Net Income | (155.2) | (208.0) | (338.8) | (83.8) | (65.8) | (80.9) | (78.3) | (44.3) | (27.2) | (21.7) | (11.3) | (10.3) |
| Per Share Data | ||||||||||||
| EPS (Basic) | -1.98 | -3.18 | -46.15 | -24.86 | -25.02 | -37.89 | -61.23 | -53.25 | -45.01 | -55.40 | -24.71 | -18.91 |
| EPS (Diluted) | -1.98 | -3.18 | -46.15 | -24.86 | -25.02 | -37.89 | -61.23 | -53.25 | -45.01 | -55.40 | -24.71 | -18.91 |
| Shares Outstanding | 346.0 | 47.0 | 6.9 | 3.4 | 2.6 | 2.1 | 1.3 | 0.8 | 0.6 | 0.4 | 0.5 | 0.5 |
| Metric | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|
| Current Assets | ||||||||||
| Cash & Cash Equivalents | 85.7 | 89.4 | 188.9 | 34.9 | 15.1 | 90.1 | 19.3 | 22.5 | 12.8 | 47.7 |
| Short-Term Investments | 670.8 | 513.7 | 150.4 | 20.8 | 78.0 | 56.2 | 52.7 | 52.1 | 37.5 | 15.8 |
| Net Receivables | 0 | 0 | 0 | 0.4 | 0.8 | 0 | 0 | 0 | 3.1 | 1.2 |
| Inventory | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Current Assets | 21.2 | 5.4 | 2.3 | 6.2 | 0 | 0 | 0 | 0 | 0 | 0 |
| Total Current Assets | 777.8 | 608.5 | 341.5 | 62.3 | 98.9 | 149.8 | 74.5 | 76.7 | 55.0 | 66.4 |
| Non-Current Assets | ||||||||||
| Property, Plant & Equipment | 0 | 0 | 0 | 6.7 | 8.4 | 9.9 | 7.1 | 1.0 | 0.9 | 0.6 |
| Goodwill | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Intangible Assets | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Long-Term Investments | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Current Assets | 0 | 0.0 | 0.3 | 2.2 | 2.7 | 2.0 | 1.6 | 0.1 | 0.2 | 0.0 |
| Total Non-Current Assets | 0 | 0.0 | 0.3 | 8.9 | 11.0 | 11.8 | 8.7 | 1.1 | 1.1 | 0.6 |
| Total Assets | 777.8 | 608.5 | 341.9 | 71.1 | 109.9 | 161.6 | 83.2 | 77.7 | 56.1 | 67.1 |
| Current Liabilities | ||||||||||
| Account Payables | 8.9 | 0.7 | 0.9 | 0.7 | 3.3 | 2.3 | 3.2 | 0.7 | 0.4 | 0.2 |
| Short-Term Debt | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Deferred Revenue | 0 | 0 | 0 | 0.5 | 2.4 | 0 | 0 | 0 | 0.0 | 0.1 |
| Other Current Liabilities | 49.8 | 52.8 | 5.9 | 4.9 | 5.0 | 4.2 | 3.7 | 2.8 | 3.4 | 1.5 |
| Total Current Liabilities | 58.7 | 54.1 | 32.0 | 14.7 | 20.1 | 16.4 | 18.4 | 10.2 | 5.6 | 4.0 |
| Non-Current Liabilities | ||||||||||
| Long-Term Debt | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Deferred Tax Liabilities | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Current Liabilities | 3.9 | 36.6 | 125.9 | 0 | 0 | 0.2 | 0.0 | 0.1 | 0.1 | 0.1 |
| Total Non-Current Liabilities | 3.9 | 36.6 | 125.9 | 6.2 | 5.8 | 5.3 | 4.7 | 0.1 | 0.1 | 0.1 |
| Total Liabilities | 62.5 | 90.7 | 157.8 | 20.8 | 26.0 | 21.8 | 23.1 | 10.3 | 5.7 | 4.1 |
| Stockholders' Equity | ||||||||||
| Common Stock | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Retained Earnings | (1,127.6) | (972.4) | (764.4) | (425.6) | (341.8) | (276.0) | (195.1) | (116.9) | (72.5) | (45.3) |
| Accumulated Other Comprehensive Income | 0.9 | 0.2 | 0.3 | (0.0) | (0.0) | 0.0 | 0.1 | (0.0) | (0.1) | (0.0) |
| Total Stockholders' Equity | 715.2 | 517.8 | 184.0 | 50.3 | 83.9 | 139.8 | 60.1 | 67.4 | 50.3 | 63.0 |
| Total Liabilities & Equity | 777.8 | 608.5 | 341.9 | 71.1 | 109.9 | 161.6 | 83.2 | 77.7 | 56.1 | 67.1 |
| Debt Metrics | ||||||||||
| Total Debt | 0 | 0 | 0 | 4.6 | 5.1 | 5.4 | 5.1 | 0 | 0 | 0 |
| Net Debt | (85.7) | (89.4) | (188.9) | (30.2) | (10.1) | (84.6) | (14.2) | (22.5) | (12.8) | (47.7) |
| Metric | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 |
|---|---|---|---|---|---|---|---|---|---|---|
| Operating Activities | ||||||||||
| Net Income | (155.2) | (208.0) | (338.8) | (83.8) | (65.8) | (80.9) | (78.3) | (44.3) | (27.2) | (21.7) |
| Depreciation & Amortization | (8.1) | 0 | 0.7 | 1.6 | 1.6 | 1.0 | 0.9 | 0.3 | 0.2 | 0.1 |
| Stock-Based Compensation | 37.6 | 44.8 | 25.7 | 7.1 | 8.0 | 6.3 | 0 | 0 | 0 | 0 |
| Change in Working Capital | (5.9) | (4.5) | (5.2) | (5.5) | 1.8 | (2.5) | 7.1 | 7.2 | (0.2) | 1.4 |
| Other Non-Cash Items | (37.6) | 10.3 | 217.7 | 0.8 | 0.6 | 0.6 | 3.8 | 1.9 | 4.8 | 1.1 |
| Operating Cash Flow | (169.3) | (157.4) | (99.9) | (80.1) | (53.7) | (75.8) | (65.7) | (32.2) | (24.6) | (18.8) |
| Investing Activities | ||||||||||
| Capital Expenditure | 0 | 0 | 0 | (0.0) | (0.6) | (4.3) | (1.5) | (0.4) | (0.6) | (0.2) |
| Acquisitions | 0 | 0 | 3.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Purchases of Investments | (522.2) | (599.3) | (166.8) | (39.5) | (133.1) | (129) | (91.9) | (62.2) | (64.1) | (20.4) |
| Sales/Maturities of Investments | 371.7 | 246.0 | 39.9 | 96.5 | 111.0 | 125.7 | 91.7 | 47.4 | 42.2 | 8.4 |
| Other Investing Activities | 7 | 0 | 15.5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Investing Cash Flow | (143.5) | (353.3) | (108.4) | 57.0 | (22.6) | (7.6) | (1.7) | (15.2) | (22.5) | (12.2) |
| Financing Activities | ||||||||||
| Net Debt Issuance | 0 | 0 | (0.0) | (0.4) | (0.5) | (0.0) | (0.0) | 0 | 0 | 0 |
| Stock Repurchased | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Financing Activities | (5.4) | 5.7 | (5.4) | 0.2 | 1.9 | 0.8 | 1.4 | 3.0 | 0.8 | 0.1 |
| Financing Cash Flow | 309.0 | 410.9 | 361.1 | 42.7 | 1.4 | 154.5 | 65.7 | 57.1 | 12.2 | 49.4 |
| Cash Position | ||||||||||
| Net Change in Cash | (3.7) | (99.8) | 152.8 | 19.4 | (75.0) | 71.2 | (3.2) | 9.6 | (34.9) | 18.4 |
| Cash at Beginning | 89.4 | 189.2 | 36.4 | 17.0 | 91.9 | 20.8 | 22.5 | 12.8 | 47.7 | 29.4 |
| Cash at End | 85.7 | 89.4 | 189.2 | 36.4 | 17.0 | 91.9 | 19.3 | 22.5 | 12.8 | 47.7 |
| Free Cash Flow | (169.3) | (157.4) | (99.9) | (80.2) | (54.3) | (80.1) | (67.2) | (32.6) | (25.2) | (19.1) |
| Key Metrics | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Income Statement | ||||||||||||
| Revenue | 0 | 0 | 0.9 | 2.3 | 18.7 | 0 | 0 | 3.9 | 5.2 | 4.6 | 6.1 | 0 |
| Gross Profit | (171.7) | 0 | 0.9 | 2.3 | 18.7 | (1.6) | (0.9) | 0 | 0 | 0 | 0 | (0.0) |
| Operating Income | (209.6) | (208.6) | (242.3) | (84.8) | (65.6) | (81.5) | (80.3) | (45.5) | (27.7) | (21.9) | (11.3) | (8.9) |
| Net Income | (155.2) | (208.0) | (338.8) | (83.8) | (65.8) | (80.9) | (78.3) | (44.3) | (27.2) | (21.7) | (11.3) | (10.3) |
| EPS (Diluted) | -1.98 | -3.18 | -46.15 | -24.86 | -25.02 | -37.89 | -61.23 | -53.25 | -45.01 | -55.40 | -24.71 | -18.91 |
| Balance Sheet | ||||||||||||
| Cash & Equivalents | 85.7 | 89.4 | 188.9 | 34.9 | 15.1 | 90.1 | 19.3 | 22.5 | 12.8 | 47.7 | ||
| Total Assets | 777.8 | 608.5 | 341.9 | 71.1 | 109.9 | 161.6 | 83.2 | 77.7 | 56.1 | 67.1 | ||
| Total Debt | 0 | 0 | 0 | 4.6 | 5.1 | 5.4 | 5.1 | 0 | 0 | 0 | ||
| Stockholders' Equity | 715.2 | 517.8 | 184.0 | 50.3 | 83.9 | 139.8 | 60.1 | 67.4 | 50.3 | 63.0 | ||
| Cash Flow | ||||||||||||
| Operating Cash Flow | (169.3) | (157.4) | (99.9) | (80.1) | (53.7) | (75.8) | (65.7) | (32.2) | (24.6) | (18.8) | ||
| Capital Expenditure | 0 | 0 | 0 | (0.0) | (0.6) | (4.3) | (1.5) | (0.4) | (0.6) | (0.2) | ||
| Free Cash Flow | (169.3) | (157.4) | (99.9) | (80.2) | (54.3) | (80.1) | (67.2) | (32.6) | (25.2) | (19.1) | ||