Ionis Pharmaceuticals, Inc. logo IONS - Ionis Pharmaceuticals, Inc.

Price: -- -- | CONSENSUS: Buy DETAILS
STRONG
BUY
1
BUY 19
HOLD 12
SELL 0
STRONG
SELL
0
| PRICE TARGET: $107.27 DETAILS
HIGH: $130.00
LOW: $87.00
MEDIAN: $104.00
CONSENSUS: $107.27
UPSIDE: 40.66%
Metric 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993
Revenue
Revenue 944 705.1 787.6 587.4 810.5 729.3 1,122.6 599.7 514.2 372.8 283.7 214.2 147.3 102.0 99.1 108.5 121.6 107.2 58.3 14.9 40.1 42.6 50.0 80.2 53.3 37.3 33.9 39.2 32.7 22.7 13 10.1 12.1
Cost of Revenue 16 11.2 9.1 14.1 10.8 11.9 4.4 1.8 0 0 322.3 241.8 184.0 158.5 0 0 0 0 0 0 0 0 0 0 0 (5.5) (5.2) (4.3) (3.2) (2.6) (2.8) (3.8) 22.4
Gross Profit 928 693.9 778.5 573.3 799.6 717.3 1,118.2 597.9 514.2 372.8 (38.6) (27.6) (36.7) (56.4) 99.1 108.5 121.6 107.2 0 0 0 0 0 0 0 42.8 39.1 43.5 35.9 25.3 15.8 13.9 (10.3)
Operating Expenses
R&D Expenses 916 901.5 899.6 833 643 535 466 414.6 374.6 344.3 322.3 241.8 184.0 158.5 157.4 145.2 134.6 106.4 92.6 80.6 82.5 118.5 117.0 124.1 83.7 57.0 66.4 62.2 55.9 45.7 33.2 26.5 0
SG&A Expenses 394 267.5 232.6 150.3 170.9 332.2 286.6 244.6 108.5 48.6 37.2 20.1 14.9 12.5 12.8 11.7 14.5 13.8 13.1 11.2 7.9 9.6 10.2 5.5 15.6 9.2 10.6 9.5 8.1 51.8 5.4 6 4.8
Other Expenses 0 (0.0) 0.0 0.1 15.9 22.2 (0.3) 0 0 0 (322.3) (241.8) (184.0) (158.5) 0 0 0 0 0 (0.5) 7.0 32.4 1.8 1.4 0 5.5 5.2 4.3 3.2 (43.1) 2.8 3.9 3.2
Operating Expenses 1,310 1,169.0 1,132.2 983.4 829.8 889.4 752.3 659.2 483.1 392.9 37.2 20.1 14.9 12.5 170.2 156.8 149.1 120.2 91.3 80.1 97.3 160.5 129.0 131.0 99.4 71.8 82.2 76 67.2 54.4 41.4 36.4 8
Operating Income
Operating Income (382) (475.1) (353.7) (410.2) (30.2) (172.1) 365.9 (61.4) 31.0 (20.2) (75.8) (47.7) (51.7) (68.9) (71.1) (48.4) (27.5) (13.1) (32.9) (65.2) (57.2) (117.9) (79.0) (50.8) (46.1) (29.0) (43.1) (32.5) (31.3) (29.1) (25.6) (22.5) (18.3)
Interest Expense 73 90.5 81.5 8.1 9.3 9.5 48.8 44.8 44.8 38.8 36.7 22.2 19.4 21.2 16.7 13.2 12.7 5.6 7.6 9.0 20.3 22.6 0 0 0 0 0 0 0 0 0 0 0
Interest Income 0 107.0 89.0 25.3 10.0 30.6 52.2 30.2 8.2 5.4 4.3 2.7 2.1 1.8 2.4 3.4 6.4 11.3 11.4 6.0 5.1 3.0 0 0 0 0 0 0 0 0 0 0 0
Profitability
EBITDA (286.7) (353.7) (235.9) (227.8) (5.2) (111.2) 367.2 (18.8) 36.3 (9.6) (40.9) (22.8) (37.4) (42.7) (56.3) (38.8) (9.8) 4.1 (26.2) (58.5) (39.8) (73.3) (64.9) (40.0) (39.1) (23.5) (37.9) (28.2) (28.1) (26.5) (22.8) (18.6) (15.1)
EBIT (307) (375.7) (258.4) (249.9) (24.7) (128.4) 351.2 (31.4) 28.0 (18.7) (51.2) (32.2) (47.2) (53.4) (68.1) (47.9) (19.1) (2.7) (32.9) (65.8) (50.2) (85.4) (77.2) (49.4) (46.1) (29.0) (43.1) (32.5) (31.3) (29.1) (25.6) (22.5) (18.3)
Income Before Tax (380) (460.1) (334.0) (258.0) (29.1) (134.6) 338.8 (76.2) (16.8) (57.5) (87.9) (54.4) (66.6) (74.6) (84.8) (61.2) (31.8) (14.5) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Income Tax Expense 1 (6.2) 32.3 11.7 (0.6) 345.2 51.5 (291.1) (6.0) 2.9 0.4 (15.4) (5.9) (9.1) 0.0 0.1 3.2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Net Income (381) (453.9) (366.3) (269.7) (28.6) (444.3) 278.1 273.7 0.3 (60.4) (88.3) (39.0) (60.6) (65.5) (84.8) (61.3) 155.1 (18.2) (11.0) (45.9) (72.4) (142.5) (95.0) (72.2) (73.8) (53.5) (59.2) (43) (31.1) (26.5) (23.7) (18.2) (19.1)
Per Share Data
EPS (Basic) -2.38 -3.04 -2.56 -1.90 -0.20 -3.18 2.10 2.07 -0.05 -0.72 -0.74 -0.33 -0.55 -0.65 -0.85 -0.62 1.58 -0.13 -0.13 -0.62 -1.15 -2.52 -1.71 -1.33 -1.67 -1.44 -2.06 -1.60 -1.17 -1.04 -1.10 -0.93 -1.22
EPS (Diluted) -2.38 -3.04 -2.56 -1.90 -0.20 -3.18 2.06 2.04 -0.05 -0.72 -0.74 -0.33 -0.55 -0.65 -0.85 -0.62 1.58 -0.13 -0.13 -0.62 -1.15 -2.52 -1.71 -1.33 -1.67 -1.44 -2.06 -1.60 -1.17 -1.04 -1.10 -0.93 -1.22
Shares Outstanding 160 149.5 143 141.8 141.0 139.6 140.0 132.3 124.0 120.8 119.3 117.7 110.5 100.6 99.7 99.1 98.1 94.6 83.7 74.3 62.9 56.6 55.5 54.5 44.1 37.0 28.7 26.9 26.6 25.5 21.5 19.6 15.7
Metric 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2009 2008 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993
Current Assets
Cash & Cash Equivalents 372.3 242.1 399.3 276.5 869.2 397.7 683.3 278.8 129.6 84.7 105.3 217.9 27.2 33.1 101.9 127.0 39.6 35.3 27.6 38.1 37.1 46.5 12.9 33.7
Short-Term Investments 2,305.2 2,055.6 1,931.9 1,720.9 1,264.0 1,494.7 1,816.3 1,805.3 893.1 2.4 469.1 273.1 76.6 182.4 187.5 185.0 87.6 17.5 0 0 0 0 0 0
Net Receivables 66 92.2 97.8 25.5 61.9 76.2 63.0 12.8 63.0 108.0 10.9 4.1 10.0 2.7 14.9 0 3.3 5.4 3.5 0 0 0 0 0
Inventory 10.0 12.5 7.4 22.0 24.8 22.0 18.2 8.6 10.0 7.5 2.8 2.7 2.7 14.0 11.1 0 0 0 0 0 0 0 0 0
Other Current Assets 247 217.9 205.4 157.7 125.2 140.2 139.8 102.5 73.1 17.2 8.1 20.5 9.0 7.4 4.8 6.4 2.6 1 32.1 51.1 42.3 32.5 32.1 21.9
Total Current Assets 2,990 2,620.3 2,641.9 2,202.7 2,345.0 2,130.7 2,720.6 2,207.9 1,168.7 797.9 596.1 518.4 125.6 239.6 320.2 328.8 133.2 59.2 63.2 89.2 79.4 79 45 55.6
Non-Current Assets
Property, Plant & Equipment 362 256.1 242.9 255.8 196.0 181.1 153.7 132.2 121.9 92.8 27.3 17.4 28.5 34.8 59.1 28.2 22.6 23.9 21.5 18.8 15.3 14.6 15.9 18.6
Goodwill 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Intangible Assets 0 0 0 0 29.0 27.9 25.7 24.0 22.0 20.4 30.5 33.1 45.2 50.7 49.7 49.1 13.8 11.3 9.1 7.5 6.2 4.8 4.1 2.6
Long-Term Investments 52.2 41.0 43.0 40.4 32.3 15.1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Other Non-Current Assets 119.4 86.3 62.3 35.0 9.3 35.0 27.6 12.9 10.1 1.3 17.8 5.3 9.2 9.9 9.8 10.9 13.6 8.7 2.3 2.4 0.4 1.2 1.6 2
Total Non-Current Assets 533.2 383.4 348.2 331.2 266.6 259.0 512.5 459.9 154.0 114.5 61.1 55.8 82.8 95.4 118.5 88.2 50.1 43.9 32.9 28.7 21.9 20.6 21.6 23.2
Total Assets 3,523.8 3,003.7 2,990.1 2,533.9 2,611.7 2,389.8 3,233.1 2,667.8 1,322.8 912.5 657.2 574.1 208.4 334.9 438.7 417.1 183.3 103.1 96.1 117.9 101.3 99.6 66.6 78.8
Current Liabilities
Account Payables 28.1 43.0 26.0 17.9 11.9 17.2 16.1 28.7 24.9 21.1 4.7 5.7 7.0 3.7 5.5 6.1 2.2 3.1 3 2.8 2.4 1 1.5 1.4
Short-Term Debt 453.1 9.3 53.2 7.5 3.5 308.8 2.0 13.7 1.6 1.2 4.3 2.1 10.5 16.5 21.4 9.8 4.6 3.9 3.6 2.3 6.2 5 2.4 4.9
Deferred Revenue 73.8 79.0 151.1 90.6 97.7 108.4 118.3 160.3 125.3 51.3 75.7 92.7 14.2 0 0 22.7 0 0 0 0 0 0 0 0
Other Current Liabilities 107.6 69.6 67.7 49.2 38.8 73.0 37.4 29.3 25.2 24.2 7.1 7.9 0 14.7 38.9 0 7.8 8 15.9 21.5 14.5 13 7.4 5.2
Total Current Liabilities 781.6 309.3 448.1 311.6 240.6 598.9 273.0 280.3 243.6 133.8 111.4 124.7 43.4 45.6 76.0 48.2 14.6 15 22.5 26.6 23.1 19 11.3 11.5
Non-Current Liabilities
Long-Term Debt 1,898.8 1,245.5 1,229.5 1,182.7 1,228.1 600.1 770.0 628.1 592.9 500.5 136.6 172.4 236.6 213.4 207.3 125.7 102.3 87.3 77.7 56.5 19.9 4.7 9.3 8.8
Deferred Tax Liabilities 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Other Non-Current Liabilities 0 542.2 513.7 0 0 23.4 15.5 4.9 13.0 15.1 0 172.8 0.5 8.8 0 20.0 0 0.0 0.1 (0.1) (0.1) 0 0 0
Total Non-Current Liabilities 2,253.2 2,106.0 2,155.3 1,649.4 1,599.4 1,047.6 1,275.6 1,200.3 713.9 679.1 243.7 345.2 237.1 222.2 207.3 145.7 102.3 87.3 77.8 56.4 19.8 4.7 9.3 8.8
Total Liabilities 3,034.7 2,415.3 2,603.4 1,961.0 1,840.0 1,646.5 1,548.6 1,480.6 957.5 812.9 355.1 469.9 280.6 267.8 283.2 194.0 116.9 102.3 100.3 83 42.9 23.7 20.6 20.3
Stockholders' Equity
Common Stock 0.2 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0 0 0 0 0 0 0
Retained Earnings (2,631.2) (2,249.8) (1,795.9) (1,429.6) (1,159.9) (1,131.3) (707.5) (967.3) (1,187.4) (1,181.4) (696.1) (839.7) (698.4) (555.6) (459.9) (386.6) (311.5) (256.8) (197.1) (154.1) (123.1) (96.5) (72.8) (54.7)
Accumulated Other Comprehensive Income (25.3) (30.8) (32.6) (57.5) (32.7) (21.1) (25.3) (32.0) (31.8) (30.4) 2.2 1.0 2.6 3.2 (0.7) 0.4 (0.7) (26.7) (22.3) (18.5) (15.6) 0 0 0
Total Stockholders' Equity 489.1 588.4 386.7 572.9 771.7 743.3 1,471.1 1,048.1 281.0 99.6 291.7 67.1 (72.1) 67.2 155.5 223.1 66.4 0.8 (4.2) 34.9 58.4 75.9 46 58.5
Total Liabilities & Equity 3,523.8 3,003.7 2,990.1 2,533.9 2,611.7 2,389.8 3,233.1 2,667.8 1,322.8 912.5 657.2 574.1 208.4 334.9 438.7 417.1 183.3 103.1 96.1 117.9 101.3 99.6 66.6 78.8
Debt Metrics
Total Debt 2,614.3 1,416.6 1,453.5 1,369.2 1,251.0 908.9 772.0 641.8 594.5 574.1 140.8 174.5 247.2 229.9 228.7 135.5 106.9 91.2 81.3 58.8 26.1 9.7 11.7 13.7
Net Debt 2,242.1 1,174.5 1,054.3 1,092.7 381.9 511.3 88.7 363.0 464.9 489.4 35.6 (43.4) 219.9 196.8 126.8 8.5 67.2 55.9 53.7 20.7 (11) (36.8) (1.2) (20)
Metric 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993
Operating Activities
Net Income (381.4) (453.9) (366.3) (269.7) (28.6) (486.8) 303.3 215.0 (17.3) (86.6) (72.4) (142.5) (95.0) (72.2) (73.8) (53.5) (59.2) (43) (31.1) (26.5) (23.7) (18.2) (19.1)
Depreciation & Amortization 22.7 19.7 22.5 22.1 19.6 17.2 16.0 12.5 8.3 9.0 9.7 12.2 12.3 10.3 7.0 5.5 5.2 4.3 3.2 2.6 2.8 3.9 3.2
Stock-Based Compensation 0 130.2 105.8 100.3 120.7 230.1 146.6 131.3 86.0 72.1 (0.5) 0.9 0 (3.0) 4.6 0 0 0 0 0 0 0 0
Change in Working Capital (51.2) (209.4) (77.3) 7.6 (113.8) (73.6) (168.7) 499.4 43.6 (151.5) (8.9) (24.2) (24.3) (18.1) 25.2 (0.9) (9.9) (7.4) 6.9 2.8 5 2.3 0.6
Other Non-Cash Items 141.3 12.5 7.7 (134.6) 7.7 35.7 55.7 35.2 39.5 34.1 9.9 52.8 11.5 (14.4) 35.5 25.7 15.5 11.4 0.4 (0.1) 0.8 (3.2) (0.1)
Operating Cash Flow (268.6) (500.9) (307.5) (274.4) 30.8 35.9 345.7 602.9 174.1 (112.1) (61.7) (101.8) (95.5) (94.4) (6.2) (23.2) (48.4) (34.7) (20.6) (21.2) (15.1) (15.2) (15.3)
Investing Activities
Capital Expenditure (51.4) (45.3) (28.0) (20.1) (17.9) (41.0) (36.3) (17.7) (37.9) (11.5) (0.4) (3.5) (7.6) (36.8) (9.3) (1.6) (4.8) (4.4) (3.5) (0.9) (1.1) (0.9) (5.2)
Acquisitions 0 0 0.0 254.1 5.9 5.9 5.4 4.0 2.5 4.5 14.0 0 0 0 0 0 0 0 0 0 0 0 0
Purchases of Investments (1,918.6) (1,852.9) (1,770.8) (1,485.8) (1,131.4) (1,570.4) (1,956.7) (1,794.7) (880.3) (300.9) (64.1) (72.5) (152.9) (200.6) (334.0) (69.9) 0 0 (8.2) (9.6) (0.4) (10.2) (0.4)
Sales/Maturities of Investments 1,697.9 1,769.2 1,584.7 989.2 1,344.2 1,885.9 1,951.7 882.8 557.4 364.6 50.2 176.1 156.9 196.1 236.2 0 13.4 17.5 0 0 0 4.2 0
Other Investing Activities (5.6) (5.1) (4.2) 0 (5.9) (5.9) (5.4) (4.0) (323.5) 63.7 0.8 (16.4) (11.6) (19.0) (36.4) (23.8) (16.5) (4) (3.5) (0.8) 0 (2.3) (1.7)
Investing Cash Flow (277.8) (134.0) (214.1) (262.6) 194.9 274.5 (41.3) (929.6) (358.3) 56.6 0.5 83.7 (15.1) (60.4) (143.5) (95.4) (7.9) 9.1 (15.2) (11.3) (1.5) (9.2) (7.3)
Financing Activities
Net Debt Issuance 483.2 (44.7) 86.9 (50.7) 313.6 0 97 0 (24.0) (3.1) (11.6) 8.1 40.2 129.6 26.6 4.6 (0.4) 11.2 36.7 23.1 50.1 3.6 2.3
Stock Repurchased 0 0 0 0 0 (90.5) (34.4) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Dividends Paid 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Other Financing Activities 0 0 507.7 (11.0) (153.3) (492.6) (82.2) 0 (2.0) 1.0 0 0 0 (8.9) 0 118.2 0 0 0 (0.1) 0 0.1 0
Financing Cash Flow 675.8 478.1 644.1 (55.3) 245.9 (596.6) 100.0 475.9 229.1 11.4 37.6 12.2 41.9 129.6 237.0 122.9 63.9 15.1 36.7 23 50.1 3.7 39.9
Cash Position
Net Change in Cash 130.2 (157.2) 122.8 (592.7) 471.5 (285.6) 404.5 149.2 44.9 (44.1) (23.6) (5.9) (68.7) (25.2) 87.4 4.3 7.7 15.1 36.7 23 50.1 3.7 39.9
Cash at Beginning 242.1 399.3 276.5 869.2 397.7 683.3 278.8 129.6 84.7 128.8 27.2 33.1 101.9 127.0 39.6 35.3 27.6 38.1 37.1 46.5 12.9 33.7 16.5
Cash at End 372.3 242.1 399.3 276.5 869.2 397.7 683.3 278.8 129.6 84.7 3.6 27.2 33.1 101.9 127.0 39.6 35.3 53.2 73.8 69.5 63 37.4 56.4
Free Cash Flow (320.0) (546.2) (335.5) (294.5) 12.9 (5.2) 309.4 585.2 136.3 (123.6) (62.2) (105.3) (103.0) (131.2) (15.4) (24.8) (53.2) (39.1) (24.1) (22.1) (16.2) (16.1) (20.5)
Key Metrics 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993
Income Statement
Revenue 944 705.1 787.6 587.4 810.5 729.3 1,122.6 599.7 514.2 372.8 283.7 214.2 147.3 102.0 99.1 108.5 121.6 107.2 58.3 14.9 40.1 42.6 50.0 80.2 53.3 37.3 33.9 39.2 32.7 22.7 13 10.1 12.1
Gross Profit 928 693.9 778.5 573.3 799.6 717.3 1,118.2 597.9 514.2 372.8 (38.6) (27.6) (36.7) (56.4) 99.1 108.5 121.6 107.2 0 0 0 0 0 0 0 42.8 39.1 43.5 35.9 25.3 15.8 13.9 (10.3)
Operating Income (382) (475.1) (353.7) (410.2) (30.2) (172.1) 365.9 (61.4) 31.0 (20.2) (75.8) (47.7) (51.7) (68.9) (71.1) (48.4) (27.5) (13.1) (32.9) (65.2) (57.2) (117.9) (79.0) (50.8) (46.1) (29.0) (43.1) (32.5) (31.3) (29.1) (25.6) (22.5) (18.3)
Net Income (381) (453.9) (366.3) (269.7) (28.6) (444.3) 278.1 273.7 0.3 (60.4) (88.3) (39.0) (60.6) (65.5) (84.8) (61.3) 155.1 (18.2) (11.0) (45.9) (72.4) (142.5) (95.0) (72.2) (73.8) (53.5) (59.2) (43) (31.1) (26.5) (23.7) (18.2) (19.1)
EPS (Diluted) -2.38 -3.04 -2.56 -1.90 -0.20 -3.18 2.06 2.04 -0.05 -0.72 -0.74 -0.33 -0.55 -0.65 -0.85 -0.62 1.58 -0.13 -0.13 -0.62 -1.15 -2.52 -1.71 -1.33 -1.67 -1.44 -2.06 -1.60 -1.17 -1.04 -1.10 -0.93 -1.22
Balance Sheet
Cash & Equivalents 372.3 242.1 399.3 276.5 869.2 397.7 683.3 278.8 129.6 84.7 105.3 217.9 27.2 33.1 101.9 127.0 39.6 35.3 27.6 38.1 37.1 46.5 12.9 33.7
Total Assets 3,523.8 3,003.7 2,990.1 2,533.9 2,611.7 2,389.8 3,233.1 2,667.8 1,322.8 912.5 657.2 574.1 208.4 334.9 438.7 417.1 183.3 103.1 96.1 117.9 101.3 99.6 66.6 78.8
Total Debt 2,614.3 1,416.6 1,453.5 1,369.2 1,251.0 908.9 772.0 641.8 594.5 574.1 140.8 174.5 247.2 229.9 228.7 135.5 106.9 91.2 81.3 58.8 26.1 9.7 11.7 13.7
Stockholders' Equity 489.1 588.4 386.7 572.9 771.7 743.3 1,471.1 1,048.1 281.0 99.6 291.7 67.1 (72.1) 67.2 155.5 223.1 66.4 0.8 (4.2) 34.9 58.4 75.9 46 58.5
Cash Flow
Operating Cash Flow (268.6) (500.9) (307.5) (274.4) 30.8 35.9 345.7 602.9 174.1 (112.1) (61.7) (101.8) (95.5) (94.4) (6.2) (23.2) (48.4) (34.7) (20.6) (21.2) (15.1) (15.2) (15.3)
Capital Expenditure (51.4) (45.3) (28.0) (20.1) (17.9) (41.0) (36.3) (17.7) (37.9) (11.5) (0.4) (3.5) (7.6) (36.8) (9.3) (1.6) (4.8) (4.4) (3.5) (0.9) (1.1) (0.9) (5.2)
Free Cash Flow (320.0) (546.2) (335.5) (294.5) 12.9 (5.2) 309.4 585.2 136.3 (123.6) (62.2) (105.3) (103.0) (131.2) (15.4) (24.8) (53.2) (39.1) (24.1) (22.1) (16.2) (16.1) (20.5)